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KMID : 0382419990250010102
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Korean Journal of Environmental Health Society
1999 Volume.25 No. 1 p.102 ~ p.108
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Effect of CCl4-induced Liver Damage on the Metabolism of Xylene in
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Lee Hye-Ja
Yoon Chong-Guk
Cho Hyun-Gug
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Abstract
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To evaluate an effect of pathological liver damage on the xylene metabolism, the rats were induced acute liver damage with 4 times of CCl_4 injection (0.1 ㎖ of 50% in olive oil/100 g body wt.) every other days. The injection of one dose xylene (0.25 ㎖ of 50% in olive oil/100 g body wt.) showed the significantly decreased urinary methylhippuric acid concentration throughout 24 hr in the liver damaged-animals than the normal group treated with only xylene. The activities of hepatic microsomal aniline hydroxylase and aldehyde dehydrogenase were significantly decreased in CCl_4 pretreated rats than the normal group at 24 hr after injection of m-xylene. Furthermore, the more severe ultrastructural changes were revealed in the hepatic cell of liver damaged-animals than in that of normal group by the injection of one dose xylene. These results suggested that the rats induced liver damage with CCl_4 may reduce the xylene metabolism.
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KEYWORD
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